Cardiac electrophysiology of adenosine. Basic and clinical concepts.

A denosine is an endogenous nucleoside that has potent electrophysiologic effects.1-4 As an antiarrhythmic agent, adenosine has several unique properties: 1) it is an intermediate metabolite (Figure 1), 2) it has a very short half-life (less than 1.5 seconds), 3) its effects are mediated by specific membrane receptors coupled to guanine nucleotide binding proteins (G proteins), and 4) it has si...

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EResearch Advances Series Cardiac Electrophysiology of Adenosine Basic and Clinical Concepts Bruce

A denosine is an endogenous nucleoside that has potent electrophysiologic effects.1-4 As an antiarrhythmic agent, adenosine has several unique properties: 1) it is an intermediate metabolite (Figure 1), 2) it has a very short half-life (less than 1.5 seconds), 3) its effects are mediated by specific membrane receptors coupled to guanine nucleotide binding proteins (G proteins), and 4) it has si...

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EResearch Advances Series Cardiac Electrophysiology of Adenosine Basic and Clinical Concepts

A denosine is an endogenous nucleoside that has potent electrophysiologic effects.1-4 As an antiarrhythmic agent, adenosine has several unique properties: 1) it is an intermediate metabolite (Figure 1), 2) it has a very short half-life (less than 1.5 seconds), 3) its effects are mediated by specific membrane receptors coupled to guanine nucleotide binding proteins (G proteins), and 4) it has si...

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The links between basic and clinical cardiac electrophysiology.

FORTY OR 50 years ago, the terms "clinical" and "basic" cardiac electrophysiology described two sides of the same coin. The clinical electrophysiologist was an electrocardiographer; the basic electrophysiologist used electrographic and electrocardiographic techniques to study the hearts of animals or isolated tissues obtained therefrom. Clinical and basic electrophysiol-ogists shared a common l...

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Basic Cardiac Electrophysiology: Excitable Membranes

D.C. Sigg et al. (eds.), Cardiac Electrophysiology Methods and Models, DOI 10.1007/978-1-4419-6658-2_2, © Springer Science + Business Media, LLC 2010 Abstract Cardiomyocytes are excitable cells that have the ability to contract after excitation; therefore, each heartbeat is an event of electrical–mechanical coupling. Cardiac electrical activity at different levels can be measured through variab...

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Cardiac electrophysiology of adenosine. Basic and clinical concepts.

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